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    Figure 2 CuET inhibits p97 segregase dependent protein degradation a CuET causes accumulation of poly ubiquitylated proteins in MCF7 cells b TNF induced IB degradation is compromised after 1 h treatment with CuET or BTZ c Dose dependent inhibition of Ub G76V GFP degradation by CuET HeLa cells were treated for 3 h n = 3 experiments d HIF 1 levels after 2 h treatments with MG132 5 M

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    Figure 1 Tumour suppressing effects of DSF and CuET a Effects of orally administered DSF and CuGlu on subcutaneous growth of MDA MB 231 tumours in mice n = 8 mice per group b CuET levels in mouse tumours and tissues n = 5 tissues n = 10 tumours c CuET levels in human plasma after DSF treatment n = 9 patients d Toxicity of DTC and CuET in MDA MB 231 cells after 24 h treatment n

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  • Figure 4 from Alcohol abuse drug disulfiram targets cancer

    NPL4GFP U2OS cells were treated with 1 M CuET for 3 h e HSF1 stress bodies in U2OS cells expressing NPL4 MUT GFP f Model of DSF anti cancer activity in patients Scale bars 10 m ae Data are representative of two independent experiments Alcohol abuse drug disulfiram targets cancer via p97 segregase adapter NPL4

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